| W | May 1May 1, 2022 | SKYLINERS vs BBC BayreuthBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 24 | 8 | 4 | 2 | 1 | 0 | 37.5% | 0.0% |
| W | Apr 29Apr 29, 2022 | HAKRO Merlins Crailsheim vs SKYLINERSBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 16 | 6 | 3 | 3 | 1 | 0 | 50.0% | 0.0% |
| L | Apr 24Apr 24, 2022 | SKYLINERS vs GIESSEN 46ersBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 36 | 6 | 7 | 3 | 0 | 0 | 18.2% | 100.0% |
| W | Apr 18Apr 18, 2022 | EWE Baskets Oldenburg vs SKYLINERSBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 18 | 0 | 0 | 1 | 1 | 0 | 0.0% | 0.0% |
| L | Apr 13Apr 13, 2022 | Veolia Towers Hamburg vs SKYLINERSBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 31 | 2 | 6 | 1 | 3 | 1 | 14.3% | 0.0% |
| L | Apr 10Apr 10, 2022 | SKYLINERS vs Telekom Baskets BonnBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 34 | 11 | 4 | 7 | 3 | 0 | 28.6% | 50.0% |
| L | Apr 6Apr 6, 2022 | BG Göttingen vs SKYLINERSBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 34 | 15 | 7 | 5 | 2 | 0 | 54.5% | 0.0% |
| L | Apr 3Apr 3, 2022 | BMA365 Bamberg Baskets vs SKYLINERSBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 32 | 2 | 4 | 3 | 2 | 0 | 12.5% | 0.0% |
| L | Mar 29Mar 29, 2022 | MLP Academics Heidelberg vs SKYLINERSBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 28 | 11 | 3 | 1 | 1 | 0 | 44.4% | 50.0% |
| L | Mar 25Mar 25, 2022 | SKYLINERS vs ratiopharm ulmBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 32 | 11 | 4 | 7 | 1 | 0 | 55.6% | 0.0% |
| W | Mar 20Mar 20, 2022 | Basketball Löwen Braunschweig vs SKYLINERSBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 31 | 5 | 2 | 2 | 0 | 0 | 40.0% | 0.0% |
| L | Mar 16Mar 16, 2022 | SKYLINERS vs Fitness First Würzburg BasketsBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 28 | 7 | 6 | 5 | 3 | 0 | 22.2% | 100.0% |
| L | Mar 13Mar 13, 2022 | SYNTAINICS MBC vs SKYLINERSBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 32 | 2 | 5 | 4 | 0 | 0 | 12.5% | 0.0% |
| L | Mar 9Mar 9, 2022 | SKYLINERS vs BG GöttingenBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 23 | 7 | 6 | 4 | 1 | 0 | 33.3% | 0.0% |
| L | Feb 15Feb 15, 2022 | SKYLINERS vs Alba BerlinBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 32 | 5 | 4 | 4 | 3 | 0 | 18.2% | 0.0% |
| L | Feb 9Feb 9, 2022 | SKYLINERS vs EWE Baskets OldenburgBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 27 | 8 | 5 | 7 | 0 | 1 | 33.3% | 66.7% |
| L | Feb 6Feb 6, 2022 | SKYLINERS vs MHP RIESEN LudwigsburgBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 22 | 2 | 1 | 5 | 0 | 0 | 0.0% | 100.0% |
| L | Jan 28Jan 28, 2022 | NINERS Chemnitz vs SKYLINERSBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 34 | 17 | 6 | 2 | 2 | 0 | 54.5% | 0.0% |
| W | Jan 2Jan 2, 2022 | GIESSEN 46ers vs SKYLINERSBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 21 | 4 | 5 | 1 | 1 | 0 | 50.0% | 0.0% |
| W | Dec 30Dec 30, 2021 | SKYLINERS vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 30 | 2 | 1 | 5 | 0 | 0 | 0.0% | 100.0% |
| L | Dec 27Dec 27, 2021 | SKYLINERS vs NINERS ChemnitzBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 34 | 11 | 3 | 4 | 4 | 0 | 28.6% | 100.0% |
| L | Dec 19Dec 19, 2021 | SKYLINERS vs SYNTAINICS MBCBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 35 | 14 | 6 | 7 | 2 | 1 | 38.5% | 80.0% |
| L | Dec 15Dec 15, 2021 | MHP RIESEN Ludwigsburg vs SKYLINERSBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 30 | 13 | 3 | 1 | 1 | 0 | 45.5% | 0.0% |
| L | Dec 11Dec 11, 2021 | BBC Bayreuth vs SKYLINERSBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 30 | 5 | 3 | 5 | 0 | 0 | 18.2% | 50.0% |
| W | Dec 5Dec 5, 2021 | SKYLINERS vs HAKRO Merlins CrailsheimBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 28 | 11 | 2 | 3 | 0 | 0 | 22.2% | 100.0% |
| L | Oct 15Oct 15, 2021 | Telekom Baskets Bonn vs SKYLINERSBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 29 | 14 | 7 | 1 | 1 | 0 | 50.0% | 83.3% |
| L | Oct 10Oct 10, 2021 | SKYLINERS vs Veolia Towers HamburgBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 29 | 17 | 7 | 3 | 2 | 0 | 35.7% | 100.0% |
| L | Sep 28Sep 28, 2021 | Alba Berlin vs SKYLINERSBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 26 | 10 | 3 | 3 | 2 | 0 | 40.0% | 0.0% |
| L | Sep 26Sep 26, 2021 | SKYLINERS vs Basketball Löwen BraunschweigBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 36 | 29 | 6 | 3 | 2 | 0 | 58.8% | 60.0% |
