| W | May 1May 1, 2022 | BG Göttingen vs GIESSEN 46ersBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 27 | 15 | 3 | 7 | 2 | 0 | 40.0% | 100.0% |
| L | Apr 29Apr 29, 2022 | GIESSEN 46ers vs NINERS ChemnitzBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 33 | 8 | 1 | 12 | 0 | 0 | 17.6% | 100.0% |
| W | Apr 24Apr 24, 2022 | SKYLINERS vs GIESSEN 46ersBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 37 | 21 | 7 | 10 | 1 | 0 | 40.0% | 81.8% |
| L | Apr 20Apr 20, 2022 | GIESSEN 46ers vs Basketball Löwen BraunschweigBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 30 | 19 | 1 | 3 | 3 | 0 | 40.0% | 87.5% |
| L | Apr 16Apr 16, 2022 | GIESSEN 46ers vs Fitness First Würzburg BasketsBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 37 | 21 | 5 | 15 | 0 | 0 | 33.3% | 71.4% |
| L | Apr 13Apr 13, 2022 | Telekom Baskets Bonn vs GIESSEN 46ersBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 33 | 23 | 2 | 8 | 2 | 0 | 47.6% | 66.7% |
| L | Apr 10Apr 10, 2022 | GIESSEN 46ers vs FC Bayern München BasketballBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 34 | 21 | 3 | 11 | 2 | 0 | 60.0% | 60.0% |
| L | Apr 2Apr 2, 2022 | MLP Academics Heidelberg vs GIESSEN 46ersBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 36 | 20 | 3 | 13 | 3 | 0 | 63.6% | 75.0% |
| W | Mar 26Mar 26, 2022 | GIESSEN 46ers vs EWE Baskets OldenburgBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 28 | 25 | 3 | 5 | 1 | 1 | 69.2% | 100.0% |
| L | Mar 17Mar 17, 2022 | SYNTAINICS MBC vs GIESSEN 46ersBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 35 | 20 | 4 | 12 | 2 | 0 | 33.3% | 33.3% |
| W | Mar 9Mar 9, 2022 | BBC Bayreuth vs GIESSEN 46ersBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 36 | 23 | 4 | 8 | 3 | 0 | 60.0% | 100.0% |
| L | Mar 6Mar 6, 2022 | GIESSEN 46ers vs MHP RIESEN LudwigsburgBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 29 | 12 | 5 | 4 | 2 | 0 | 23.1% | 60.0% |
| L | Feb 15Feb 15, 2022 | HAKRO Merlins Crailsheim vs GIESSEN 46ersBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 31 | 16 | 5 | 7 | 2 | 0 | 66.7% | 50.0% |
| L | Feb 12Feb 12, 2022 | GIESSEN 46ers vs BMA365 Bamberg BasketsBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 35 | 27 | 8 | 6 | 5 | 0 | 52.9% | 88.9% |
| W | Jan 22Jan 22, 2022 | GIESSEN 46ers vs Veolia Towers HamburgBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 34 | 22 | 10 | 8 | 6 | 1 | 66.7% | 66.7% |
| L | Jan 8Jan 8, 2022 | GIESSEN 46ers vs BG GöttingenBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 37 | 26 | 7 | 7 | 0 | 0 | 40.0% | 88.9% |
| L | Jan 2Jan 2, 2022 | GIESSEN 46ers vs SKYLINERSBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 29 | 8 | 3 | 7 | 1 | 0 | 42.9% | 25.0% |
| L | Dec 29Dec 29, 2021 | MHP RIESEN Ludwigsburg vs GIESSEN 46ersBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 30 | 10 | 4 | 5 | 2 | 0 | 28.6% | 75.0% |
| L | Dec 26Dec 26, 2021 | Veolia Towers Hamburg vs GIESSEN 46ersBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 32 | 14 | 5 | 4 | 4 | 0 | 40.0% | 83.3% |
| L | Dec 23Dec 23, 2021 | Basketball Löwen Braunschweig vs GIESSEN 46ersBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 29 | 8 | 7 | 5 | 3 | 0 | 20.0% | 60.0% |
| L | Dec 18Dec 18, 2021 | GIESSEN 46ers vs Telekom Baskets BonnBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 29 | 9 | 3 | 8 | 2 | 0 | 66.7% | 50.0% |
| L | Dec 11Dec 11, 2021 | NINERS Chemnitz vs GIESSEN 46ersBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 30 | 9 | 0 | 7 | 6 | 0 | 10.0% | 87.5% |
| L | Dec 3Dec 3, 2021 | GIESSEN 46ers vs ratiopharm ulmBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 26 | 10 | 3 | 8 | 5 | 1 | 50.0% | 100.0% |
| W | Nov 20Nov 20, 2021 | EWE Baskets Oldenburg vs GIESSEN 46ersBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 27 | 15 | 3 | 5 | 2 | 0 | 54.5% | 100.0% |
| L | Nov 6Nov 6, 2021 | GIESSEN 46ers vs HAKRO Merlins CrailsheimBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 23 | 5 | 2 | 5 | 1 | 0 | 25.0% | 100.0% |
| L | Oct 31Oct 31, 2021 | Fitness First Würzburg Baskets vs GIESSEN 46ersBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 35 | 12 | 3 | 5 | 1 | 0 | 30.0% | 62.5% |
| W | Oct 23Oct 23, 2021 | GIESSEN 46ers vs SYNTAINICS MBCBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 27 | 19 | 6 | 4 | 3 | 0 | 80.0% | 60.0% |
| L | Oct 17Oct 17, 2021 | FC Bayern München Basketball vs GIESSEN 46ersBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 28 | 5 | 3 | 8 | 2 | 0 | 25.0% | 20.0% |
| L | Oct 9Oct 9, 2021 | GIESSEN 46ers vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | Basketball Bundesliga (BBL) | 30 | 9 | 1 | 7 | 4 | 0 | 50.0% | 100.0% |
