| L | May 11May 11, 2022 | MHP RIESEN Ludwigsburg vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | 98–83 | Basketball Bundesliga (BBL) | 19 | 9 | 4 | 1 | 1 | 0 | 60.0% | 50.0% |
| L | May 1May 1, 2022 | Alba Berlin vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | 110–70 | Basketball Bundesliga (BBL) | 22 | 9 | 3 | 0 | 1 | 0 | 27.3% | 100.0% |
| L | Apr 29Apr 29, 2022 | MLP Academics Heidelberg vs BMA365 Bamberg BasketsBasketball Bundesliga (BBL) | 81–94 | Basketball Bundesliga (BBL) | 21 | 14 | 2 | 2 | 2 | 0 | 57.1% | 100.0% |
| L | Apr 23Apr 23, 2022 | MLP Academics Heidelberg vs EWE Baskets OldenburgBasketball Bundesliga (BBL) | 90–95 | Basketball Bundesliga (BBL) | 29 | 17 | 8 | 2 | 1 | 0 | 33.3% | 100.0% |
| L | Apr 18Apr 18, 2022 | MLP Academics Heidelberg vs Telekom Baskets BonnBasketball Bundesliga (BBL) | 71–82 | Basketball Bundesliga (BBL) | 23 | 19 | 1 | 1 | 2 | 0 | 53.3% | 100.0% |
| L | Apr 12Apr 12, 2022 | ratiopharm ulm vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | 90–74 | Basketball Bundesliga (BBL) | 17 | 4 | 2 | 0 | 0 | 0 | 50.0% | 100.0% |
| L | Apr 9Apr 9, 2022 | HAKRO Merlins Crailsheim vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | 87–72 | Basketball Bundesliga (BBL) | 26 | 17 | 8 | 0 | 1 | 0 | 35.7% | 100.0% |
| W | Apr 2Apr 2, 2022 | MLP Academics Heidelberg vs GIESSEN 46ersBasketball Bundesliga (BBL) | 95–81 | Basketball Bundesliga (BBL) | 22 | 15 | 0 | 2 | 1 | 0 | 42.9% | 100.0% |
| W | Mar 29Mar 29, 2022 | MLP Academics Heidelberg vs SKYLINERSBasketball Bundesliga (BBL) | 71–65 | Basketball Bundesliga (BBL) | 35 | 19 | 4 | 3 | 1 | 0 | 42.9% | 50.0% |
| L | Mar 26Mar 26, 2022 | MLP Academics Heidelberg vs Veolia Towers HamburgBasketball Bundesliga (BBL) | 76–100 | Basketball Bundesliga (BBL) | 20 | 10 | 1 | 2 | 1 | 0 | 50.0% | 85.7% |
| W | Mar 23Mar 23, 2022 | BG Göttingen vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | 70–82 | Basketball Bundesliga (BBL) | 29 | 9 | 5 | 7 | 2 | 1 | 57.1% | 100.0% |
| L | Mar 19Mar 19, 2022 | Fitness First Würzburg Baskets vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | 97–77 | Basketball Bundesliga (BBL) | 21 | 15 | 4 | 1 | 1 | 0 | 50.0% | 100.0% |
| W | Mar 12Mar 12, 2022 | MLP Academics Heidelberg vs Basketball Löwen BraunschweigBasketball Bundesliga (BBL) | 81–78 | Basketball Bundesliga (BBL) | 26 | 12 | 2 | 2 | 1 | 0 | 25.0% | 77.8% |
| W | Feb 16Feb 16, 2022 | MLP Academics Heidelberg vs SYNTAINICS MBCBasketball Bundesliga (BBL) | 94–70 | Basketball Bundesliga (BBL) | 28 | 22 | 3 | 2 | 2 | 0 | 58.3% | 100.0% |
| L | Feb 12Feb 12, 2022 | BBC Bayreuth vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | 85–79 | Basketball Bundesliga (BBL) | 37 | 15 | 4 | 0 | 1 | 0 | 35.7% | 100.0% |
| L | Feb 5Feb 5, 2022 | MLP Academics Heidelberg vs NINERS ChemnitzBasketball Bundesliga (BBL) | 66–81 | Basketball Bundesliga (BBL) | 14 | 4 | 1 | 0 | 0 | 0 | 25.0% | 100.0% |
| L | Feb 2Feb 2, 2022 | EWE Baskets Oldenburg vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | 109–73 | Basketball Bundesliga (BBL) | 15 | 0 | 2 | 2 | 0 | 0 | 0.0% | 0.0% |
| L | Jan 23Jan 23, 2022 | MLP Academics Heidelberg vs FC Bayern München BasketballBasketball Bundesliga (BBL) | 70–92 | Basketball Bundesliga (BBL) | 25 | 8 | 1 | 0 | 1 | 0 | 40.0% | 100.0% |
| W | Jan 15Jan 15, 2022 | Basketball Löwen Braunschweig vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | 82–93 | Basketball Bundesliga (BBL) | 32 | 15 | 3 | 6 | 1 | 1 | 30.0% | 100.0% |
| W | Jan 7Jan 7, 2022 | MLP Academics Heidelberg vs HAKRO Merlins CrailsheimBasketball Bundesliga (BBL) | 100–91 | Basketball Bundesliga (BBL) | 26 | 11 | 4 | 1 | 0 | 0 | 80.0% | 66.7% |
| L | Dec 30Dec 30, 2021 | SKYLINERS vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | 87–82 | Basketball Bundesliga (BBL) | 26 | 17 | 4 | 1 | 1 | 1 | 55.6% | 87.5% |
| L | Dec 19Dec 19, 2021 | MLP Academics Heidelberg vs Alba BerlinBasketball Bundesliga (BBL) | 81–83 | Basketball Bundesliga (BBL) | 25 | 9 | 2 | 1 | 1 | 0 | 42.9% | 100.0% |
| L | Dec 10Dec 10, 2021 | Telekom Baskets Bonn vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | 87–70 | Basketball Bundesliga (BBL) | 30 | 12 | 5 | 1 | 1 | 0 | 44.4% | 75.0% |
| L | Dec 6Dec 6, 2021 | FC Bayern München Basketball vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | 77–71 | Basketball Bundesliga (BBL) | 30 | 15 | 1 | 0 | 3 | 0 | 45.5% | 80.0% |
| L | Dec 4Dec 4, 2021 | MLP Academics Heidelberg vs BG GöttingenBasketball Bundesliga (BBL) | 80–96 | Basketball Bundesliga (BBL) | 22 | 8 | 4 | 1 | 0 | 0 | 50.0% | 20.0% |
| L | Nov 21Nov 21, 2021 | NINERS Chemnitz vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | 67–64 | Basketball Bundesliga (BBL) | 28 | 7 | 6 | 1 | 1 | 0 | 22.2% | 100.0% |
| L | Nov 6Nov 6, 2021 | MLP Academics Heidelberg vs BBC BayreuthBasketball Bundesliga (BBL) | 87–89 | Basketball Bundesliga (BBL) | 30 | 16 | 3 | 4 | 1 | 0 | 42.9% | 100.0% |
| L | Oct 29Oct 29, 2021 | Veolia Towers Hamburg vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | 81–75 | Basketball Bundesliga (BBL) | 29 | 7 | 1 | 0 | 2 | 0 | 37.5% | 50.0% |
| W | Oct 23Oct 23, 2021 | MLP Academics Heidelberg vs Fitness First Würzburg BasketsBasketball Bundesliga (BBL) | 76–71 | Basketball Bundesliga (BBL) | 32 | 9 | 3 | 2 | 1 | 0 | 40.0% | 0.0% |
| L | Oct 17Oct 17, 2021 | BMA365 Bamberg Baskets vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | 72–68 | Basketball Bundesliga (BBL) | 31 | 7 | 4 | 3 | 1 | 0 | 27.3% | 0.0% |
| W | Oct 9Oct 9, 2021 | GIESSEN 46ers vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | 68–75 | Basketball Bundesliga (BBL) | 33 | 28 | 5 | 2 | 1 | 0 | 45.0% | 90.0% |
| W | Sep 29Sep 29, 2021 | MLP Academics Heidelberg vs MHP RIESEN LudwigsburgBasketball Bundesliga (BBL) | 73–67 | Basketball Bundesliga (BBL) | 38 | 23 | 7 | 4 | 0 | 0 | 26.7% | 100.0% |
| W | Sep 25Sep 25, 2021 | SYNTAINICS MBC vs MLP Academics HeidelbergBasketball Bundesliga (BBL) | 74–85 | Basketball Bundesliga (BBL) | 33 | 14 | 8 | 2 | 2 | 0 | 50.0% | 50.0% |
